A Cas-embedding strategy for minimizing off-target effects of DNA base editors

DNA base editors, typically comprising editing enzymes fused to the N-terminus of nCas9, display off-target effects on DNA and/or RNA, which have remained an obstacle to their clinical applications. Off-target edits are typically countered via rationally designed point mutations, but the approach is...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Liu, Yajing, Zhou, Changyang, Huang, Shisheng, Dang, Lu, Wei, Yu, He, Jun, Zhou, Yingsi, Mao, Shaoshuai, Tao, Wanyu, Zhang, Yu, Yang, Hui, Huang, Xingxu, Chi, Tian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7695861/
https://ncbi.nlm.nih.gov/pubmed/33247095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19690-0
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