Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer’s disease pathologies

Netrin-1, a family member of laminin-related secreted proteins, mediates axon guidance and cell migration during neural development. T835M mutation in netrin receptor UNC5C predisposes to the late-onset Alzheimer’s disease (AD) and increases neuronal cell death. However, it remains unclear how this...

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Publicado en:Sci Adv
Autores principales: Chen, Guiqin, Kang, Seong Su, Wang, Zhihao, Ahn, Eun Hee, Xia, Yiyuan, Liu, Xia, Sandoval, Ivette M., Manfredsson, Fredric P., Zhang, Zhaohui, Ye, Keqiang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8051868/
https://ncbi.nlm.nih.gov/pubmed/33863723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe4499
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