Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2

Peroxiredoxin 2 (Prdx2) is a thiol peroxidase with an active site Cys (C52) that reacts rapidly with H(2)O(2) and other peroxides. The sulfenic acid product condenses with the resolving Cys (C172) to form a disulfide which is recycled by thioredoxin or GSH via mixed disulfide intermediates or underg...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Peskin, Alexander V., Meotti, Flavia C., Kean, Kelsey M., Göbl, Christoph, Peixoto, Albert Souza, Pace, Paul E., Horne, Christopher R., Heath, Sarah G., Crowther, Jennifer M., Dobson, Renwick C.J., Karplus, P. Andrew, Winterbourn, Christine C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049995/
https://ncbi.nlm.nih.gov/pubmed/33667550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100494
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