Model for the Exceptional Reactivity of Peroxiredoxins 2 and 3 with Hydrogen Peroxide: A KINETIC AND COMPUTATIONAL STUDY

Peroxiredoxins (Prx) are thiol peroxidases that exhibit exceptionally high reactivity toward peroxides, but the chemical basis for this is not well understood. We present strong experimental evidence that two highly conserved arginine residues play a vital role in this activity of human Prx2 and Prx...

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Bibliografiske detaljer
Main Authors: Nagy, Péter, Karton, Amir, Betz, Andrea, Peskin, Alexander V., Pace, Paul, O'Reilly, Robert J., Hampton, Mark B., Radom, Leo, Winterbourn, Christine C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093878/
https://ncbi.nlm.nih.gov/pubmed/21385867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.232355
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