Hyperoxidation of Peroxiredoxins 2 and 3: RATE CONSTANTS FOR THE REACTIONS OF THE SULFENIC ACID OF THE PEROXIDATIC CYSTEINE

Typical 2-Cys peroxiredoxins (Prxs) react rapidly with H(2)O(2) to form a sulfenic acid, which then condenses with the resolving cysteine of the adjacent Prx in the homodimer or reacts with another H(2)O(2) to become hyperoxidized. Hyperoxidation inactivates the Prx and is implicated in cell signali...

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Main Authors: Peskin, Alexander V., Dickerhof, Nina, Poynton, Rebecca A., Paton, Louise N., Pace, Paul E., Hampton, Mark B., Winterbourn, Christine C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Enzymology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656273/
https://ncbi.nlm.nih.gov/pubmed/23543738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.460881
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