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Glutathionylation of the Active Site Cysteines of Peroxiredoxin 2 and Recycling by Glutaredoxin

Peroxiredoxin 2 (Prx2) is a thiol protein that functions as an antioxidant, regulator of cellular peroxide concentrations, and sensor of redox signals. Its redox cycle is widely accepted to involve oxidation by a peroxide and reduction by thioredoxin/thioredoxin reductase. Interactions of Prx2 with...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Peskin, Alexander V., Pace, Paul E., Behring, Jessica B., Paton, Louise N., Soethoudt, Marjolein, Bachschmid, Markus M., Winterbourn, Christine C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742766/
https://ncbi.nlm.nih.gov/pubmed/26601956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.692798
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