Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins

2-Cys peroxiredoxins (Prxs) modulate hydrogen peroxide (H(2)O(2))-mediated cell signaling. At high H(2)O(2) levels, eukaryotic Prxs can be inactivated by hyperoxidation and are classified as sensitive Prxs. In contrast, prokaryotic Prxs are categorized as being resistant to hyperoxidation and lack t...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bolduc, Jesalyn A., Nelson, Kimberly J., Haynes, Alexina C., Lee, Jingyun, Reisz, Julie A., Graff, Aaron H., Clodfelter, Jill E., Parsonage, Derek, Poole, Leslie B., Furdui, Cristina M., Lowther, W. Todd
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066324/
https://ncbi.nlm.nih.gov/pubmed/29884768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001690
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