Differential Peroxiredoxin Hyperoxidation Regulates MAP Kinase Signaling in Human Articular Chondrocytes

The peroxiredoxin (Prx) family of Cys-dependent peroxidases control intracellular levels of H(2)O(2) and can regulate signal transduction. Inhibition of the Prxs, through hyperoxidation amongst other mechanisms, leads to oxidative stress conditions that can alter homeostatic signaling. To determine...

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Bibliographic Details
Published in:Free Radic Biol Med
Main Authors: Collins, John A., Wood, Scott T., Bolduc, Jesalyn A., Nurmalasari, N.P. Dewi, Chubinskaya, Susan, Poole, Leslie B., Furdui, Cristina M., Nelson, Kimberly J., Loeser, Richard F.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588440/
https://ncbi.nlm.nih.gov/pubmed/30639614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2019.01.005
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