Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes

Oxidative stress-mediated post-translational modifications of redox-sensitive proteins are postulated as a key mechanism underlying age-related cellular dysfunction and disease progression. Peroxiredoxins (PRX) are critical intracellular antioxidants that also regulate redox signaling events. Age-re...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Collins, John A., Wood, Scott T., Nelson, Kimberly J., Rowe, Meredith A., Carlson, Cathy S., Chubinskaya, Susan, Poole, Leslie B., Furdui, Cristina M., Loeser, Richard F.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807251/
https://ncbi.nlm.nih.gov/pubmed/26797130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.693523
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