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Differential Kinetics of Two-Cysteine Peroxiredoxin Disulfide Formation Reveal a Novel Model for Peroxide Sensing

Two-cysteine peroxiredoxins (Prx) have a three-step catalytic cycle consisting of (1) reduction of peroxide and formation of sulfenic acid on the enzyme, (2) condensation of the sulfenic acid with a thiol to form disulfide, also known as resolution, and (3) reduction of the disulfide by a reductant...

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Détails bibliographiques
Publié dans:Biochemistry
Auteurs principaux: Portillo-Ledesma, Stephanie, Randall, Lía M., Parsonage, Derek, Dalla Rizza, Joaquín, Karplus, P. Andrew, Poole, Leslie B., Denicola, Ana, Ferrer-Sueta, Gerardo
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383210/
https://ncbi.nlm.nih.gov/pubmed/29553725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00188
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