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Dissecting Peroxiredoxin Catalysis: Separating Binding, Peroxidation, and Resolution for a Bacterial AhpC

Peroxiredoxins make up a ubiquitous family of cysteine-dependent peroxidases that reduce hydroperoxide or peroxynitrite substrates through formation of a cysteine sulfenic acid (R-SOH) at the active site. In the 2-Cys peroxiredoxins, a second (resolving) cysteine reacts with the sulfenic acid to for...

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Publicat a:Biochemistry
Autors principals: Parsonage, Derek, Nelson, Kimberly J., Ferrer-Sueta, Gerardo, Alley, Samantha, Karplus, P. Andrew, Furdui, Cristina M., Poole, Leslie B.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489686/
https://ncbi.nlm.nih.gov/pubmed/25633283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501515w
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