Bortezomib Inhibits Hypoxia-Induced Proliferation by Suppressing Caveolin-1/SOCE/[Ca(2+)](i) Signaling Axis in Human PASMCs

BACKGROUND: Previous studies have demonstrated the ubiquitin-proteasome inhibitor bortezomib (BTZ) can effectively alleviate hypoxia-induced pulmonary hypertension (HPH) by suppressing the intracellular calcium homeostasis in pulmonary arterial smooth muscle cells (PASMCs). Further evaluation showed...

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Pubblicato in:Biomed Res Int
Autori principali: Wang, Chao, Li, Yuanqi, Xu, Lei, Zhang, Qiang, Gegentuya, Tian, Guoying
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049800/
https://ncbi.nlm.nih.gov/pubmed/33928148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/5551504
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