Rab26 promotes hypoxia-induced hyperproliferation of PASMCs by modulating the AT1R-STAT3-YAP axis

Abstract The hyper-proliferation of pulmonary artery smooth muscle cells (PASMCs) significantly contributes to pulmonary vascular remodeling (PVR) in chronic hypoxic pulmonary arterial hypertension (PAH), leading to right ventricular dysfunction and increased mortality. Despite the critical role of...

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Autori principali:	Zaichun You, Qiuhong Huang, Li Zeng, Xin Tian, Wen Zhang, Dongqin Wei, Juan Fu, Liling Xu, Li Ren, Yan Zhao, Hang Qian, Guansong Wang, Xunmei Zhou, Binfeng He
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer 2025-11-01
Serie:	Cellular and Molecular Life Sciences
Soggetti:	Rab26 AT1R STAT3 YAP1 PVR
Accesso online:	https://doi.org/10.1007/s00018-025-05923-2
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