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The Development of a Fluorescence‐Based Competitive Assay Enabled the Discovery of Dimeric Cyclic Peptide Modulators of Ubiquitin Chains

Development of modulators targeting specific interactions of ubiquitin‐based conjugates with their partners is a formidable task since it requires a suitable screening assay and homogeneous ubiquitin conjugates. We developed a novel high‐throughput strategy for screening ligands for Lys48‐linked tet...

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Bibliografske podrobnosti
izdano v:Angew Chem Int Ed Engl
Main Authors: Vamisetti, Ganga B., Meledin, Roman, Nawatha, Mickal, Suga, Hiroaki, Brik, Ashraf
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048552/
https://ncbi.nlm.nih.gov/pubmed/33326152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202013392
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