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Examining the role of phosphorylation of p19(INK4d) in its stability and ubiquitination using chemical protein synthesis

p19(INK4d) plays an important role in the regulation of the cell cycle by inhibiting the function of cyclin-dependent kinases 4/6 that is responsible for the phosphorylation and deactivation of the retinoblastoma protein (pRb) tumour suppressor. Recently, it was reported that phosphorylation of p19(...

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Publicado en:Chem Sci
Main Authors: Msallam, Muna, Sun, Hao, Meledin, Roman, Franz, Pauline, Brik, Ashraf
Formato: Artigo
Idioma:Inglês
Publicado: Royal Society of Chemistry 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446725/
https://ncbi.nlm.nih.gov/pubmed/32874495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc06300e
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