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Examining the role of phosphorylation of p19(INK4d) in its stability and ubiquitination using chemical protein synthesis

p19(INK4d) plays an important role in the regulation of the cell cycle by inhibiting the function of cyclin-dependent kinases 4/6 that is responsible for the phosphorylation and deactivation of the retinoblastoma protein (pRb) tumour suppressor. Recently, it was reported that phosphorylation of p19(...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Msallam, Muna, Sun, Hao, Meledin, Roman, Franz, Pauline, Brik, Ashraf
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446725/
https://ncbi.nlm.nih.gov/pubmed/32874495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc06300e
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