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N-Methylcysteine-Mediated Total Chemical Synthesis of Ubiquitin Thioester
Ubiquitin thioester is a key intermediate in the ubiquitylation of proteins and is formed enzymatically through the activation of α-COOH of ubiquitin in an ATP dependent manner using the E1 enzyme. The current methods used for the preparation of ubiquitin thioester rely on either the enzymatic machi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3183995/ https://ncbi.nlm.nih.gov/pubmed/20448897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c000332h |
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