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Total chemical synthesis of ester-linked ubiquitinated proteins unravels their behavior with deubiquitinases

Ester-linked ubiquitinated proteins have been reported by several groups to be involved in ubiquitin signalling. However, due to the lack of the suitable tools to homogeneously produce such conjugates, their exact physiological roles and biochemical behavior remain enigmatic. Here, we report for the...

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Détails bibliographiques
Publié dans:Chem Sci
Auteurs principaux: Sun, Hao, Meledin, Roman, Mali, Sachitanand M., Brik, Ashraf
Format: Artigo
Langue:Inglês
Publié: Royal Society of Chemistry 2018
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887810/
https://ncbi.nlm.nih.gov/pubmed/29675213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc04518b
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