De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains

A promising approach in cancer therapy is to find ligands that directly bind ubiquitin (Ub) chains. However, finding molecules capable of tightly and specifically binding Ub chains is challenging given the range of Ub polymer lengths and linkages and their subtle structural differences. Here, we use...

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Gepubliceerd in:Nat Chem
Hoofdauteurs: Nawatha, Mickal, Rogers, Joseph, Bonn, Steven M., Livneh, Ido, Lemma, Betsegaw, Mali, Sachitanand M., Vamisetti, Ganga B., Sun, Hao, Bercovich, Beatrice, Huang, Yichao, Ciechanover, Aaron, Fushman, David, Suga, Hiroaki, Brik, Ashraf
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341950/
https://ncbi.nlm.nih.gov/pubmed/31182821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-019-0278-x
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