De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains

A promising approach in cancer therapy is to find ligands that directly bind ubiquitin (Ub) chains. However, finding molecules capable of tightly and specifically binding Ub chains is challenging given the range of Ub polymer lengths and linkages and their subtle structural differences. Here, we use...

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Detalhes bibliográficos
Publicado no:Nat Chem
Main Authors: Nawatha, Mickal, Rogers, Joseph, Bonn, Steven M., Livneh, Ido, Lemma, Betsegaw, Mali, Sachitanand M., Vamisetti, Ganga B., Sun, Hao, Bercovich, Beatrice, Huang, Yichao, Ciechanover, Aaron, Fushman, David, Suga, Hiroaki, Brik, Ashraf
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341950/
https://ncbi.nlm.nih.gov/pubmed/31182821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-019-0278-x
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