De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains

A promising approach in cancer therapy is to find ligands that directly bind ubiquitin (Ub) chains. However, finding molecules capable of tightly and specifically binding Ub chains is challenging given the range of Ub polymer lengths and linkages and their subtle structural differences. Here, we use...

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Publicado en:Nat Chem
Main Authors: Nawatha, Mickal, Rogers, Joseph, Bonn, Steven M., Livneh, Ido, Lemma, Betsegaw, Mali, Sachitanand M., Vamisetti, Ganga B., Sun, Hao, Bercovich, Beatrice, Huang, Yichao, Ciechanover, Aaron, Fushman, David, Suga, Hiroaki, Brik, Ashraf
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341950/
https://ncbi.nlm.nih.gov/pubmed/31182821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-019-0278-x
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