A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis

Caspase-11, a cytosolic lipopolysaccharide (LPS) receptor, mediates lethal immune responses and coagulopathy in sepsis, a leading cause of death worldwide with limited therapeutic options. We previously showed that over-activation of caspase-11 is driven by hepatocyte-released high mobility group bo...

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Pubblicato in:Cell Death Dis
Autori principali: Wang, Xiangyu, Li, Zhaozheng, Bai, Yang, Zhang, Rui, Meng, Ran, Chen, Fangping, Wang, Haichao, Billiar, Timothy R., Xiao, Xianzhong, Lu, Ben, Tang, Yiting
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8047024/
https://ncbi.nlm.nih.gov/pubmed/33854044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03652-5
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