The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis

Caspase-11, a cytosolic endotoxin (lipopolysaccharide: LPS) receptor, mediates pyroptosis, a lytic form of cell death. Caspase-11-dependent pyroptosis mediates lethality in endotoxemia, but it is unclear how LPS is delivered into the cytosol for the activation of caspase-11. Here we discovered that...

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Publicado no:Immunity
Main Authors: Deng, Meihong, Tang, Yiting, Li, Wenbo, Wang, Xiangyu, Zhang, Rui, Zhang, Xianying, Zhao, Xin, Liu, Jian, Tang, Cheng, Liu, Zhonghua, Huang, Yongzhuo, Peng, Huige, Xiao, Lehui, Tang, Daolin, Scott, Melanie J., Wang, Qingde, Liu, Jing, Xiao, Xianzhong, Watkins, Simon, Li, Jianhua, Yang, Huan, Wang, Haichao, Chen, Fangping, Tracey, Kevin J., Billiar, Timothy R., Lu, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300139/
https://ncbi.nlm.nih.gov/pubmed/30314759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.08.016
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