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A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis
Caspase-11, a cytosolic lipopolysaccharide (LPS) receptor, mediates lethal immune responses and coagulopathy in sepsis, a leading cause of death worldwide with limited therapeutic options. We previously showed that over-activation of caspase-11 is driven by hepatocyte-released high mobility group bo...
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| Publicado no: | Cell Death Dis |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8047024/ https://ncbi.nlm.nih.gov/pubmed/33854044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03652-5 |
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