TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis

BACKGROUND: Caspase-11, a cytosolic receptor of bacterial endotoxin (lipopolysaccharide: LPS), mediates immune responses and lethality in endotoxemia and experimental sepsis. However, the upstream pathways that regulate caspase-11 activation in endotoxemia and sepsis are not fully understood. The ai...

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Detalhes bibliográficos
Publicado no:Mol Med
Main Authors: Tang, Yiting, Zhang, Rui, Xue, Qianqian, Meng, Ran, Wang, Xiangyu, Yang, Yanliang, Xie, Lingli, Xiao, Xianzhong, Billiar, Timothy R., Lu, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307235/
https://ncbi.nlm.nih.gov/pubmed/30587103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-018-0065-y
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