TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis

Abstract Background Caspase-11, a cytosolic receptor of bacterial endotoxin (lipopolysaccharide: LPS), mediates immune responses and lethality in endotoxemia and experimental sepsis. However, the upstream pathways that regulate caspase-11 activation in endotoxemia and sepsis are not fully understood...

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Detalhes bibliográficos
Main Authors: Yiting Tang, Rui Zhang, Qianqian Xue, Ran Meng, Xiangyu Wang, Yanliang Yang, Lingli Xie, Xianzhong Xiao, Timothy R. Billiar, Ben Lu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-12-01
Colecção:Molecular Medicine
Assuntos:
Non-canonical inflammasome
Caspase-11
Innate immunity
Sepsis
Acesso em linha:http://link.springer.com/article/10.1186/s10020-018-0065-y
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