Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with hepatitis C virus envelope glycoproteins

Human IGHV1-69-encoded broadly neutralizing antibodies (bnAbs) that target the hepatitis C virus (HCV) envelope glycoprotein (Env) E2 are important for protection against HCV infection. An IGHV1-69 ortholog gene, VH1.36, is preferentially used for bnAbs isolated from HCV Env-immunized rhesus macaque...

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Bibliografiset tiedot
Julkaisussa:Immunity
Päätekijät: Chen, Fang, Tzarum, Netanel, Lin, Xiaohe, Giang, Erick, Velázquez-Moctezuma, Rodrigo, Augestad, Elias H., Nagy, Kenna, He, Linling, Hernandez, Mayda, Fouch, Mallorie E., Escuer, Ariadna Grinyó i, Chavez, Deborah, Doranz, Benjamin J., Prentoe, Jannick, Stanfield, Robyn L., Lanford, Robert, Bukh, Jens, Wilson, Ian A., Zhu, Jiang, Law, Mansun
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2021
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8046733/
https://ncbi.nlm.nih.gov/pubmed/33675683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2021.02.013
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