Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with hepatitis C virus envelope glycoproteins

Human IGHV1-69-encoded broadly neutralizing antibodies (bnAbs) that target the hepatitis C virus (HCV) envelope glycoprotein (Env) E2 are important for protection against HCV infection. An IGHV1-69 ortholog gene, VH1.36, is preferentially used for bnAbs isolated from HCV Env-immunized rhesus macaque...

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Publicado en:Immunity
Main Authors: Chen, Fang, Tzarum, Netanel, Lin, Xiaohe, Giang, Erick, Velázquez-Moctezuma, Rodrigo, Augestad, Elias H., Nagy, Kenna, He, Linling, Hernandez, Mayda, Fouch, Mallorie E., Escuer, Ariadna Grinyó i, Chavez, Deborah, Doranz, Benjamin J., Prentoe, Jannick, Stanfield, Robyn L., Lanford, Robert, Bukh, Jens, Wilson, Ian A., Zhu, Jiang, Law, Mansun
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8046733/
https://ncbi.nlm.nih.gov/pubmed/33675683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2021.02.013
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