Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with hepatitis C virus envelope glycoproteins

Human IGHV1-69-encoded broadly neutralizing antibodies (bnAbs) that target the hepatitis C virus (HCV) envelope glycoprotein (Env) E2 are important for protection against HCV infection. An IGHV1-69 ortholog gene, VH1.36, is preferentially used for bnAbs isolated from HCV Env-immunized rhesus macaque...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Immunity
Prif Awduron: Chen, Fang, Tzarum, Netanel, Lin, Xiaohe, Giang, Erick, Velázquez-Moctezuma, Rodrigo, Augestad, Elias H., Nagy, Kenna, He, Linling, Hernandez, Mayda, Fouch, Mallorie E., Escuer, Ariadna Grinyó i, Chavez, Deborah, Doranz, Benjamin J., Prentoe, Jannick, Stanfield, Robyn L., Lanford, Robert, Bukh, Jens, Wilson, Ian A., Zhu, Jiang, Law, Mansun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8046733/
https://ncbi.nlm.nih.gov/pubmed/33675683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2021.02.013
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