Hepatitis C Virus–Escape Studies for Human Monoclonal Antibody AR4A Reveal Isolate-Specific Resistance and a High Barrier to Resistance

Global control of hepatitis C virus (HCV) depends on development of a prophylactic vaccine. We studied escape for cross-genotype–reactive neutralizing antibody AR4A, providing valuable information for HCV vaccine design. We cultured HCV core-NS2 recombinants H77 (genotype 1a)/JFH1 or the highly anti...

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Detalles Bibliográficos
Publicado en:J Infect Dis
Main Authors: Velázquez-Moctezuma, Rodrigo, Galli, Andrea, Law, Mansun, Bukh, Jens, Prentoe, Jannick
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
Assuntos:
Major Articles and Brief Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6455953/
https://ncbi.nlm.nih.gov/pubmed/30102355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy481
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