Hypervariable region 1 shielding of hepatitis C virus is a main contributor to genotypic differences in neutralization sensitivity

There are 3-4 million new hepatitis C virus (HCV) infections yearly. The extensive inter-genotypic sequence diversity of envelope proteins E1 and E2 of HCV and shielding of important epitopes by hypervariable region 1 (HVR1) of E2 are believed to be major hindrances to developing universally protect...

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Udgivet i:Hepatology
Main Authors: Prentoe, Jannick, Velázquez-Moctezuma, Rodrigo, Foung, Steven K. H., Law, Mansun, Bukh, Jens
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115964/
https://ncbi.nlm.nih.gov/pubmed/27351277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28705
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