QSM is an imaging biomarker for chronic glial activation in multiple sclerosis lesions

BACKGROUND: Inflammation in chronic active lesions occurs behind a closed blood–brain barrier and cannot be detected with MRI. Activated microglia are highly enriched for iron and can be visualized with quantitative susceptibility mapping (QSM), an MRI technique used to delineate iron. OBJECTIVE: To...

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Detalhes bibliográficos
Publicado no:Ann Clin Transl Neurol
Main Authors: Gillen, Kelly M., Mubarak, Mayyan, Park, Calvin, Ponath, Gerald, Zhang, Shun, Dimov, Alexey, Levine‐Ritterman, Maya, Toro, Steven, Huang, Weiyuan, Amici, Stephanie, Kaunzner, Ulrike W., Gauthier, Susan A., Guerau‐de‐Arellano, Mireia, Wang, Yi, Nguyen, Thanh D., Pitt, David
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045922/
https://ncbi.nlm.nih.gov/pubmed/33704933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.51338
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