Cyclophilin A Inhibitor Debio-025 Targets Crk, Reduces Metastasis, and Induces Tumor Immunogenicity in Breast Cancer

The Crk adaptor protein, a critical modifier of multiple signaling pathways, is overexpressed in many cancers where it contributes to tumor progression and metastasis. Recently, we have shown that Crk interacts with the peptidyl prolyl cis-trans isomerase, Cyclophilin A (CypA; PP1A) via a G(219)P(22...

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Bibliografiset tiedot
Julkaisussa:Mol Cancer Res
Päätekijät: Davra, Viralkumar, Saleh, Tamjeed, Geng, Ke, Kimani, Stanley, Mehta, Dhriti, Kasikara, Canan, Smith, Brendan, Colangelo, Nicholas W., Ciccarelli, Bryan, Li, Hong, Azzam, Edouard I., Kalodimos, Charalampos G., Birge, Raymond B., Kumar, Sushil
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045419/
https://ncbi.nlm.nih.gov/pubmed/32321766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-1144
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