Methylglyoxal induces p53 activation and inhibits mTORC1 in human umbilical vein endothelial cells

Methylglyoxal (MGO), a precursor of advanced glycation end products (AGEs), is regarded as a pivotal mediator of vascular damage in patients with diabetes. We have previously reported that MGO induces transcriptional changes compatible with p53 activation in cultured human endothelial cells. To furt...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Zhang, Xinmiao, Rodriguez-Niño, Angelica, Pastene, Diego O., Pallavi, Prama, van den Born, Jacob, Bakker, Stephan J. L., Krämer, Bernhard K., Yard, Benito A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044125/
https://ncbi.nlm.nih.gov/pubmed/33850227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87561-9
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