Methylglyoxal down-regulates the expression of cell cycle associated genes and activates the p53 pathway in human umbilical vein endothelial cells

Although methylglyoxal (MGO) has emerged as key mediator of diabetic microvascular complications, the influence of MGO on the vascular transcriptome has not thoroughly been assessed. Since diabetes is associated with low grade inflammation causing sustained nuclear factor-kappa B (NF-κB) activation,...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Braun, Jana D., Pastene, Diego O., Breedijk, Annette, Rodriguez, Angelica, Hofmann, Björn B., Sticht, Carsten, von Ochsenstein, Elke, Allgayer, Heike, van den Born, Jacob, Bakker, Stephan, Hauske, Sibylle J., Krämer, Bernhard K., Yard, Benito A., Albrecht, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362029/
https://ncbi.nlm.nih.gov/pubmed/30718683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37937-1
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi