Methylglyoxal down-regulates the expression of cell cycle associated genes and activates the p53 pathway in human umbilical vein endothelial cells

Although methylglyoxal (MGO) has emerged as key mediator of diabetic microvascular complications, the influence of MGO on the vascular transcriptome has not thoroughly been assessed. Since diabetes is associated with low grade inflammation causing sustained nuclear factor-kappa B (NF-κB) activation,...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Braun, Jana D., Pastene, Diego O., Breedijk, Annette, Rodriguez, Angelica, Hofmann, Björn B., Sticht, Carsten, von Ochsenstein, Elke, Allgayer, Heike, van den Born, Jacob, Bakker, Stephan, Hauske, Sibylle J., Krämer, Bernhard K., Yard, Benito A., Albrecht, Thomas
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362029/
https://ncbi.nlm.nih.gov/pubmed/30718683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37937-1
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