Monoclonal Antibody RYSK173 Recognizes the Dinuclear Zn Center of Serum Carnosinase 1 (CN-1): Possible Consequences of Zn Binding for CN-1 Recognition by RYSK173

BACKGROUND AND AIMS: The proportion of serum carnosinase (CN-1) recognized by RYSK173 monoclonal antibody negatively correlates with CN-1 activity. We thus hypothesized that the epitope recognized by RYSK173 is accessible only in a catalytically incompetent conformation of the zinc dependent enzyme...

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Pubblicato in:PLoS One
Autori principali: Zhang, Shiqi, Lindner, Holger A., Kabtni, Sarah, van den Born, Jaap, Bakker, Stephan, Navis, Gerjan, Krämer, Bernard, Yard, Benito, Hauske, Sibylle
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4723063/
https://ncbi.nlm.nih.gov/pubmed/26799971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146831
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