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Structural Basis for High-Affinity Trapping of the Na(V)1.7 Channel in its Resting State by Tarantula Toxin
Voltage-gated sodium channels initiate electrical signals and are frequently targeted by deadly gating-modifier neurotoxins, including tarantula toxins, which trap the voltage sensor in its resting state. The structural basis for tarantula-toxin action remains elusive, because of the difficulty of c...
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| Опубликовано в: : | Mol Cell |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8043720/ https://ncbi.nlm.nih.gov/pubmed/33232657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.10.039 |
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