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Structural Basis for High-Affinity Trapping of the Na(V)1.7 Channel in its Resting State by Tarantula Toxin

Voltage-gated sodium channels initiate electrical signals and are frequently targeted by deadly gating-modifier neurotoxins, including tarantula toxins, which trap the voltage sensor in its resting state. The structural basis for tarantula-toxin action remains elusive, because of the difficulty of c...

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Bibliografische gegevens
Gepubliceerd in:Mol Cell
Hoofdauteurs: Wisedchaisri, Goragot, Tonggu, Lige, Gamal El-Din, Tamer M., McCord, Eedann, Zheng, Ning, Catterall, William A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043720/
https://ncbi.nlm.nih.gov/pubmed/33232657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.10.039
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