TFEB Links MYC Signaling to Epigenetic Control of Myeloid Differentiation and Acute Myeloid Leukemia

MYC oncoproteins regulate transcription of genes directing cell proliferation, metabolism, and tumorigenesis. A variety of alterations drive MYC expression in acute myeloid leukemia (AML), and enforced MYC expression in hematopoietic progenitors is sufficient to induce AML. Here we report that AML a...

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Veröffentlicht in:Blood Cancer Discov
Hauptverfasser: Yun, Seongseok, Vincelette, Nicole D., Yu, Xiaoqing, Watson, Gregory W., Fernandez, Mario R., Yang, Chunying, Hitosugi, Taro, Cheng, Chia-Ho, Freischel, Audrey R., Zhang, Ling, Li, Weimin, Hou, Hsinan, Schaub, Franz X., Vedder, Alexis R., Cen, Ling, McGraw, Kathy L., Moon, Jungwon, Murphy, Daniel J., Ballabio, Andrea, Kaufmann, Scott H., Berglund, Anders E., Cleveland, John L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for Cancer Research 2020
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043621/
https://ncbi.nlm.nih.gov/pubmed/33860275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2643-3230.BCD-20-0029
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