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The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective
The autophagy–lysosomal pathway (ALP) is involved in the degradation of long-lived proteins. Deficits in the ALP result in protein aggregation, the generation of toxic protein species, and accumulation of dysfunctional organelles, which are hallmarks of Alzheimer's disease (AD), Parkinson'...
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| Publicat a: | Trends Neurosci |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4928589/ https://ncbi.nlm.nih.gov/pubmed/26968346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tins.2016.02.002 |
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