Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300

SARS-CoV-2 encodes main protease (M(pro)), an attractive target for therapeutic interventions. We show M(pro) is susceptible to glutathionylation leading to inhibition of dimerization and activity. Activity of glutathionylated M(pro) could be restored with reducing agents or glutaredoxin. Analytical...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Davis, David A., Bulut, Haydar, Shrestha, Prabha, Yaparla, Amulya, Jaeger, Hannah K., Hattori, Shin-ichiro, Wingfield, Paul T., Mitsuya, Hiroaki, Yarchoan, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043447/
https://ncbi.nlm.nih.gov/pubmed/33851157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.04.09.439169
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