Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300

SARS-CoV-2 encodes main protease (M(pro)), an attractive target for therapeutic interventions. We show M(pro) is susceptible to glutathionylation leading to inhibition of dimerization and activity. Activity of glutathionylated M(pro) could be restored with reducing agents or glutaredoxin. Analytical...

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Publicado en:bioRxiv
Autores principales: Davis, David A., Bulut, Haydar, Shrestha, Prabha, Yaparla, Amulya, Jaeger, Hannah K., Hattori, Shin-ichiro, Wingfield, Paul T., Mitsuya, Hiroaki, Yarchoan, Robert
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043447/
https://ncbi.nlm.nih.gov/pubmed/33851157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.04.09.439169
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