Structural details of amyloid β oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy

Human PrP (huPrP) is a high-affinity receptor for oligomeric amyloid β (Aβ) protein aggregates. Binding of Aβ oligomers to membrane-anchored huPrP has been suggested to trigger neurotoxic cell signaling in Alzheimer’s disease, while an N-terminal soluble fragment of huPrP can sequester Aβ oligomers...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: König, Anna S., Rösener, Nadine S., Gremer, Lothar, Tusche, Markus, Flender, Daniel, Reinartz, Elke, Hoyer, Wolfgang, Neudecker, Philipp, Willbold, Dieter, Heise, Henrike
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8042448/
https://ncbi.nlm.nih.gov/pubmed/33667547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100499
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