Origin of metastable oligomers and their effects on amyloid fibril self-assembly

Assembly of rigid amyloid fibrils with their characteristic cross-β sheet structure is a molecular signature of numerous neurodegenerative and non-neuropathic disorders. Frequently large populations of small globular amyloid oligomers (gOs) and curvilinear fibrils (CFs) precede the formation of late...

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Veröffentlicht in:Chem Sci
Hauptverfasser: Hasecke, Filip, Miti, Tatiana, Perez, Carlos, Barton, Jeremy, Schölzel, Daniel, Gremer, Lothar, Grüning, Clara S. R., Matthews, Garrett, Meisl, Georg, Knowles, Tuomas P. J., Willbold, Dieter, Neudecker, Philipp, Heise, Henrike, Ullah, Ghanim, Hoyer, Wolfgang, Muschol, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2018
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050532/
https://ncbi.nlm.nih.gov/pubmed/30079208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc01479e
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