Structural details of amyloid β oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy

Human PrP (huPrP) is a high-affinity receptor for oligomeric amyloid β (Aβ) protein aggregates. Binding of Aβ oligomers to membrane-anchored huPrP has been suggested to trigger neurotoxic cell signaling in Alzheimer’s disease, while an N-terminal soluble fragment of huPrP can sequester Aβ oligomers...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Biol Chem
Hlavní autoři: König, Anna S., Rösener, Nadine S., Gremer, Lothar, Tusche, Markus, Flender, Daniel, Reinartz, Elke, Hoyer, Wolfgang, Neudecker, Philipp, Willbold, Dieter, Heise, Henrike
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8042448/
https://ncbi.nlm.nih.gov/pubmed/33667547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100499
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky