Design and In Vitro Evaluation of Splice-Switching Oligonucleotides Bearing Locked Nucleic Acids, Amido-Bridged Nucleic Acids, and Guanidine-Bridged Nucleic Acids

Our group previously developed a series of bridged nucleic acids (BNAs), including locked nucleic acids (LNAs), amido-bridged nucleic acids (AmNAs), and guanidine-bridged nucleic acids (GuNAs), to impart specific characteristics to oligonucleotides such as high-affinity binding and enhanced enzymati...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Shimo, Takenori, Nakatsuji, Yusuke, Tachibana, Keisuke, Obika, Satoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8037388/
https://ncbi.nlm.nih.gov/pubmed/33805378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22073526
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