Amido-Bridged Nucleic Acid-Modified Antisense Oligonucleotides Targeting SYT13 to Treat Peritoneal Metastasis of Gastric Cancer

Patients with peritoneal metastasis of gastric cancer have dismal prognosis, mainly because of inefficient systemic delivery of drugs to peritoneal tumors. We aimed to develop an intraperitoneal treatment strategy using amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides (ASOs) tar...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Kanda, Mitsuro, Kasahara, Yuuya, Shimizu, Dai, Miwa, Takashi, Umeda, Shinichi, Sawaki, Koichi, Nakamura, Shunsuke, Kodera, Yasuhiro, Obika, Satoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644579/
https://ncbi.nlm.nih.gov/pubmed/33230476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.10.001
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