Amido-Bridged Nucleic Acid-Modified Antisense Oligonucleotides Targeting SYT13 to Treat Peritoneal Metastasis of Gastric Cancer

Patients with peritoneal metastasis of gastric cancer have dismal prognosis, mainly because of inefficient systemic delivery of drugs to peritoneal tumors. We aimed to develop an intraperitoneal treatment strategy using amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides (ASOs) tar...

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發表在:Mol Ther Nucleic Acids
Main Authors: Kanda, Mitsuro, Kasahara, Yuuya, Shimizu, Dai, Miwa, Takashi, Umeda, Shinichi, Sawaki, Koichi, Nakamura, Shunsuke, Kodera, Yasuhiro, Obika, Satoshi
格式: Artigo
語言:Inglês
出版: American Society of Gene & Cell Therapy 2020
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644579/
https://ncbi.nlm.nih.gov/pubmed/33230476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.10.001
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