Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson’s disease

Parkinson’s disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. A characteristic pathological feature of PD is cytoplasmic accumulation of α-synuclein (SNCA) protein. Multiplication of the SNCA gene in familial PD and pathological accumulat...

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Publicado no:Sci Rep
Main Authors: Uehara, Takuya, Choong, Chi-Jing, Nakamori, Masayuki, Hayakawa, Hideki, Nishiyama, Kumiko, Kasahara, Yuuya, Baba, Kousuke, Nagata, Tetsuya, Yokota, Takanori, Tsuda, Hiroshi, Obika, Satoshi, Mochizuki, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527855/
https://ncbi.nlm.nih.gov/pubmed/31110191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43772-9
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