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Design and evaluation of locked nucleic acid-based splice-switching oligonucleotides in vitro
Antisense-mediated modulation of pre-mRNA splicing is an attractive therapeutic strategy for genetic diseases. Currently, there are few examples of modulation of pre-mRNA splicing using locked nucleic acid (LNA) antisense oligonucleotides, and, in particular, no systematic study has addressed the op...
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| Главные авторы: | , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4081108/ https://ncbi.nlm.nih.gov/pubmed/24935206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku512 |
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