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A Crowding Barrier to Protein Inhibition in Colloidal Aggregates
Small molecule colloidal aggregates adsorb and partially denature proteins, inhibiting them artifactually. Oddly, this inhibition is typically time-dependent. Two mechanisms might explain this: low concentrations of the colloid and enzyme might mean low encounter rates, or colloid-based protein dena...
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| Publicado no: | J Med Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8035302/ https://ncbi.nlm.nih.gov/pubmed/33761256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c02253 |
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